Combustion synthesis of AlN doped with carbon and oxygen

Carbon-and-oxygen-doped AlN specimens were prepared by combustion synthesis using Al, graphite, and AlN. Graphite addition changed the product color from white to blue. By XRD, the lattice constant increased slightly with increasing carbon content. Blue AlN powder was synthesized with a molar ratio of the diluent AlN of 0.2-0.5 with a fixed graphite content of 0.05. At an AlN molar ratio exceeding 0.6, carbon was not successfully incorporated due to the lower reaction temperature. Calcination at 800°C in air removed residual graphite without changing the crystal structure or product color. Oxygen, nitrogen, and carbon analyses revealed that blue AlN powders contained 0.45-0.54 mass% carbon and 1.4-1.6 mass% oxygen, while the undoped AlN contained 0.021 mass% carbon and 0.94 mass% oxygen. The origin of the white-to-blue color change was investigated via reflection measurements. Blue AlN exhibits an absorption peak at 634 nm (1.96 eV). From first-principles electronic structure calculations, the C-doped AlN and carbon-and-oxygen-doped AlN with a 1:1 ratio could be classified as p-type, whereas the O-doped AlN and 1:3 carbon-and-oxygen-doped AlN were n-type. One reason for the absorption peak at 634 nm may be a transition from the conduction band to an upper unoccupied state. These results suggest the possible control of optical and electronic properties of AlN via carbon-and-oxygen doping.     

Rational Designs for Lithium-Sulfur Batteries with Low Electrolyte/Sulfur Ratio

Lithium-sulfur batteries (LSBs) are considered a promising next-generation energy storage device owing to their high theoretical energy density. However, their overall performance is limited by several critical issues such as lithium polysulfide (PS) shuttles, low sulfur utilization, and unstable Li metal anodes. Despite recent huge progress, the electrolyte/sulfur ratio (E/S) used is usually very high (≥20 µL mg⁻¹), which greatly reduces the practical energy density of devices. To push forward LSBs from the lab to the industry, considerable attention is devoted to reducing E/S while ensuring the electrochemical performance. To date, however, few reviews have comprehensively elucidated the possible strategies to achieve that purpose. In this review, recent advances in low E/S cathodes and anodes based on the issues resulting from low E/S and the corresponding solutions are summarized. These will be beneficial for a systematic understanding of the rational design ideas and research trends of low E/S LSBs. In particular, three strategies are proposed for cathodes: preventing PS formation/aggregation to avoid inadequate dissolution, designing multifunctional macroporous networks to address incomplete infiltration, and utilizing an imprison strategy to relieve the adsorption dependence on specific surface area. Finally, the challenges and future prospects for low E/S LSBs are discussed.     

TiO2/MXene-Assisted LDI-MS for Urine Metabolic Profiling in Urinary Disease

Cancer remains an intractable medical problem. Rapid diagnosis and identification of cancer are critical to differentiate it from nonmalignant diseases. High-throughput biofluid metabolic analysis has potential for cancer diagnosis. Nevertheless, the present metabolite analysis method does not meet the demand for high-throughput screening of diseases. Herein, a high-throughput, cost-effective, and noninvasive urine metabolic profiling method based on TiO₂/MXene-assisted laser desorption/ionization mass spectrometry (LDI-MS) is presented for the efficient screening of bladder cancer (BC) and nonmalignant urinary disease. Combined with machine learning, TiO₂/MXene-assisted LDI-MS enables high diagnostic accuracy (96.8%) for the classification of patient groups (including 47 BC and 46 ureteral calculus (UC) patients) from healthy controls (113 cases). In addition, BC patients can also be identified from noncancerous UC individuals with an accuracy of 88.3% in the independent test cohort. Furthermore, metabolite variations between BC and UC individuals are investigated based on relative quantification, and related pathways are also discussed. These results suggest that this method, based on urine metabolic patterns, provides a potential tool for rapidly distinguishing urinary diseases and it may pave the way for precision medicine.     

Interfacial Crystallization of Diacylglycerols Rich in Medium‐ and Long‐Chain Fatty Acids in Water‐in‐Oil Emulsions

The effects of diacylglycerols rich in medium‐ and long‐chain fatty acids (MLCD) on the crystallization of hydrogenated palm oil (HPO) and formation of 10% water‐in‐oil (W/O) emulsion are studied, and compared with the common surfactants monostearoylglycerol (MSG) and polyglycerol polyricinoleate (PGPR). Polarized light microscopy reveals that emulsions made with MLCD form crystals around dispersed water droplets and promotes HPO crystallization at the oil‐water interface. Similar behavior is also observed in MSG‐stabilized emulsions, but is absent from emulsions made with PGPR. The large deformation yield value of the test W/O emulsion is increased four‐fold versus those stabilized via PGPR due to interfacial crystallization of HPO. However, there are no large differences in droplet size, solid fat content (SFC), thermal behavior or polymorphism to account for these substantial changes, implying that the spatial distribution of the HPO crystals within the crystal network is the driving factor responsible for the observed textural differences. MLCD‐covered water droplets act as active fillers and interact with surrounding fat crystals to enhance the rigidity of emulsion. This study provides new insights regarding the use of MLCD in W/O emulsions as template for interfacial crystallization and the possibility of tailoring their large deformation behavior. Practical Applications: MLCD is applied in preparing W/O emulsion. It is found that MLCD forms unique interfacial Pickering crystals around water droplets, which promote the surface‐inactive HPO nucleation at the oil‐water interface. Thus MLCD‐covered water droplets act as active fillers and interact with surrounding fat crystals, which can greatly enhance the rigidity of emulsion. This observation would provide a theoretical reference and practical basis for the application of the MLCD with appreciable nutritional properties in lipid‐rich products such as whipped cream, shortenings margarine, butter and ice cream, so as to substitute hydrogenated oil. MLCD‐stabilized emulsions can also be explored for the development of novel confectionery products, lipsticks, or controlled release matrices.     

酸改性CoPd/TiO2催化CH4-CO2直接合成C2含氧化合物

采用酸处理方法对CoPd/TiO₂催化剂进行改性，并将酸改性催化剂用于温和条件下CH₄-CO₂梯阶转化直接合成C₂含氧化合物（乙酸和乙醇）的反应。在150～300℃考察了浸酸方式和不同种类酸处理对催化剂活性和选择性的影响。采用X射线衍射（XRD）、X射线光电子能谱（XPS）、NH₃程序升温脱附（NH₃-TPD）和N₂吸附对催化剂进行了表征。结果表明，酸改性明显提高了CoPd/TiO₂上C₂含氧化合物的生成速率和选择性。浸酸方式对催化剂性能和结构有显著影响，先用酸浸渍载体然后再浸渍活性金属所得催化剂具有更高的活性。在H₃PO₄、HNO₃和HCl中，H₃PO₄浸渍的催化剂活性最佳，在150℃时C₂含氧化合物（乙酸和乙醇）的生成速率为3365 μg/(g·h)，选择性达到91%。     

基于ABAQUS的显式动力学分析方法研究

显式动力学(The Explicit Dynamic)是针对隐式求解器的一个补充,其分析方法对于求解广泛、各类非线性结构力学问题是一个非常有效的工具,显式方法中的单个增量步取决于模型的最高固有频率,与持续时间、载荷类型无关。ABAQUS/Explicit主要用于碰撞、接触以及失效分析。探讨了ABAQUS显式动力学的基本理论、求解的问题,对显示动力学分析方法中的求解算法、稳定时间极限和能量平衡问题进行研究,给出了显示动力学分析的一般性分析方法。通过案例验证了该方法的可行性,应用该方法可有效解决实际工业生产中的碰撞问题、复杂的接触问题以及复杂的后屈曲问题,可为显式动力学分析方法应用于工程实践奠定理论与方法基础。     

A modified cross-correlation algorithm for PIV image processing of particle-fluid two-phase flow

PIV (Particle Image Velocimetry) technique for flow field measurement has achieved popular self-identify through over ten years development, and its application range is becoming wider and wider. PIV post-processing techniques have a great influence on the success of particle-fluid two-phase flow field measurement and thus become a hot and difficult topic. In the present study, a Phase Respective Identification Algorithm (PRIA) is introduced to separate low-density solid particles or bubbles and high-density tracer particles from the PIV image of particle-fluid two-phase flow. PTV (Particle Tracking Velocimetry) technique is employed to calculate the velocity fields of low-density solid particles or bubbles. For the velocity fields of high-density solid particles or bubble phase and continuous phase traced by high-density smaller particles, based on the thought of wavelet transform and multi-resolution analysis and the theory of cross-correlation of image, a delaminated processing algorithm (MCCWM) is presented to conquer the limitation of conventional Fourier transform. The algorithm is firstly testified on synthetic two-phase flows, such as uniform steady flow, shearing flow and rotating flow, and the computational results from the simulated particle images are in reasonable agreement with the given simulated data. The algorithm is then applied to images of actual bubble-liquid two-phase flow and jet flow, and the results also confirmed that the algorithm proposed in the present study has good performance and reliability for post-processing PIV images of particle-fluid two-phase flow.     

Quantitative UPLC‐MS/MS analysis of chlorogenic acid derivatives in antioxidant fractionates from dandelion (Taraxacum officinale) root

While qualitative studies have identified chlorogenic acids in antioxidant extracts, particularly ethyl acetate‐derived extracts, of Taraxacum officinale, quantitative analysis of these phenolic compounds remains largely unreported for this species. In this study, bioactivity‐guided fractionation of an antioxidant crude ethyl acetate extract (DPPH = 295.481 ± 0.955 mg TE g^?1 extract) from T. officinale root resulted in a number of reverse‐phase fractions that demonstrated high antioxidant activity (DPPH = 1058.733–1312.136 mg TE g^?1 extract), stronger than that of the synthetic antioxidant Trolox^®. UPLC‐MS/MS screening of these fractions for the presence of selected mono‐ and di‐caffeoylquinic acids revealed large quantities of 1,5‐dicaffeoylquinic acid present in several fractions (853.052–907.324 μg mg^?1), respectively. Due to the antioxidant potency and high levels of 1,5‐dicaffeoylquinic acid observed in these fractions, it was concluded that specifically this chlorogenic acid derivative is a major contributor to the antioxidant efficacy of dandelion root.     

Ni-P/HZSM-5催化木质素降解制备酚类化学品

采用Ni-P复合改性HZSM-5催化剂催化木质素降解制备高附加值的单酚类化学品，探讨了催化剂种类、金属负载量、反应温度、反应时间以及溶剂种类对木质素催化降解制备酚类化合物的影响。同时采用X射线衍射仪（XRD）、比表面积和孔径分析仪（BET）、化学吸附仪（NH₃-TPD）、热重分析仪（TG）以及气相色谱质谱联用仪（GC/MS）对催化剂以及液相产物进行分析表征，同时探讨其催化失活以及再生机制。结果表明：Ni、P高度分散在HZSM-5催化剂的表面，Ni的添加有效地弱化了C－C键，致使β-O-4和α-O-4发生断裂，有效地提高了木质素加氢解聚的活性，减少了焦炭的生成，但催化剂的再生水热稳定性较差，重复使用性较低。当采用甲醇为供氢试剂，在反应温度为220℃，氢气压力为2MPa，反应时间为8h，催化剂负载量为10%，NaOH为共催化剂时，其木质素的转化率为98.6%，酚类化合物的含量达到74.97%。产物以苯酚、愈创木酚和紫丁香酚为主，低温促进了紫丁香酚的产生。     

诺氟沙星片在中国健康受试者空腹和餐后状态下生物等效性研究#br#

目的：采用随机、开放、两周期、自身交叉、单次给药试验设计比较浙江医药股份有限公司新昌制药厂生产的诺氟沙星片与原研产品BACCIDAL在中国健康人体中的生物利用度，并评价两种制剂的生物等效性。方法：分别在空腹和餐后条件下，健康受试者随机交叉单剂量口服诺氟沙星片受试制剂或参比制剂100 mg，采用液相色谱-质谱串联（LC-MS/MS）法测定受试者服药前后不同时间点血浆内药物浓度，采用WinNonlin 7.0软件计算主要药代动力学参数，并评价两种制剂的生物等效性。结果：空腹试验共有28例受试者入组并完成试验，诺氟沙星受试制剂与参比制剂的Cmax分别为（607.62±125.24）ng/mL和（552.01±134.11）ng/mL；AUC0-t分别为（2 551.66±509.08）ng·mL-1·h和（2 429.98±460.47）ng·mL-1·h；AUC0-∞分别为（2 675.40±523.04）ng·mL-1·h和（2 557.68±485.43）ng·mL-1·h；t1/2分别为（6.07±0.69）h和（6.18±0.92）h；两种制剂的Cmax、AUC0-t和AUC0-∞几何均值比的90%置信区间分别为101.45%～121.94%、98.96%～111.27%、98.82%～110.76%。餐后试验共有28例受试者入组并完成试验，诺氟沙星受试制剂与参比制剂的Cmax分别为：（256.54±58.87）ng/mL和（300.80±94.67）ng/mL；AUC0-t分别为（1 314.74±349.92）ng·mL-1·h和（1 278.60±314.77）ng·mL-1·h；AUC0-∞分别为（1 413.73±361.98）ng·mL-1·h和（1 374.98±321.62）ng·mL-1·h；t1/2分别为（6.66±1.23）h和（6.66±1.34）h；两种制剂的Cmax、AUC0-t和AUC0-∞几何均值比的90%置信区间分别为81.42%～93.56%、99.61%～105.58%、99.80%～105.21%。结论：浙江医药股份有限公司新昌制药厂生产的诺氟沙星片与原研产品BACCIDAL在中国健康受试者空腹和餐后服用的状态下等效且安全性良好，临床上可以替换使用。